Works with a plain adapter
Samsung NX sits 5.50mm further from the sensor than Canon RF. You need a 5.50mm adapter, but it can be a plain one — a hollow metal spacer with no glass in it. The lens still reaches infinity focus and nothing is added to the optical path.
Coverage & framing. Samsung NX lenses are built for a APS-C imaging circle, which is smaller than Full frame. Expect heavy vignetting or a forced crop on a Canon RF body.